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广泛性社交恐惧症中杏仁核在高低强度情绪面孔刺激下的反应性:一项4特斯拉功能磁共振成像研究

Amygdala reactivity to emotional faces at high and low intensity in generalized social phobia: a 4-Tesla functional MRI study.

作者信息

Yoon K Lira, Fitzgerald Daniel A, Angstadt Mike, McCarron Rosemary A, Phan K Luan

机构信息

Brain Imaging and Emotions Laboratory, Department of Psychiatry, University of Chicago, Chicago, IL 60637-1470, USA.

出版信息

Psychiatry Res. 2007 Jan 15;154(1):93-8. doi: 10.1016/j.pscychresns.2006.05.004. Epub 2006 Nov 9.

Abstract

Using functional magnetic resonance imaging, we measured amygdala reactivity to faces varying on emotional intensity in subjects with generalized social phobia (GSP) and matched healthy controls, and observed greater bilateral activation to high (vs. low) intensity expressions in the phobic group, suggesting that more arousing social-emotional cues contribute to limbic hyperactivity in GSP.

摘要

通过功能磁共振成像,我们测量了广泛性社交恐惧症(GSP)患者和匹配的健康对照者杏仁核对不同情绪强度面部表情的反应性,并观察到恐惧症组对高强度(相对于低强度)表情的双侧激活更强,这表明更具刺激性的社会情感线索会导致GSP患者边缘系统过度活跃。

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