在一名有过宫内死亡史的孕妇中，通过分子KEL*6,7分型支持抗KEL7（抗Js(b)）同种免疫诊断。

Anti-KEL7 (anti-Js(b)) alloimmunization diagnostic supported by molecular KEL*6,7 typing in a pregnant woman with previous intrauterine deaths.

作者信息

Boturão-Neto Edmir, Chiba Akemi Kuroda, Oliveira Barros Melca Maria, Barretto de Mello Adriana, Fabron Antonio, Orlando Bordin José

机构信息

Disciplina de Hematologia e Hemoterapia, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Botucatu, 740, São Paulo 04023-092, SP, Brazil.

出版信息

Transfus Apher Sci. 2006 Dec;35(3):217-21. doi: 10.1016/j.transci.2006.09.004. Epub 2006 Nov 9.

DOI:10.1016/j.transci.2006.09.004

PMID:17097348

Abstract

Anti-KEL7 (anti-Js(b)) is a rare antibody that has been related to haemolytic transfusion reactions and HDN. We report a case of anti-KEL7 alloimmunization detected in a pregnant woman who had an obstetric previous history of four miscarriages and one stillborn. Employing classical immunohematological techniques, we studied the propositus and her available relatives. Due to the unavailability of commercial anti-KEL6 and anti-KEL7 reagents, we used a KEL6,7 genotyping method as an alternative tool to contribute with the identification of the alloantibody origin. The results of KEL genotyping showed that the propositus was KEL6/6 homozygous, while her second partner was KEL*7/7 homozygous.

摘要

抗KEL7（抗Js(b)）是一种罕见抗体，与溶血性输血反应和新生儿溶血病相关。我们报告一例在一名有4次流产和1次死产产科病史的孕妇中检测到抗KEL7同种免疫的病例。我们采用经典免疫血液学技术对该先证者及其可及亲属进行了研究。由于缺乏商用抗KEL6和抗KEL7试剂，我们使用KEL6,7基因分型方法作为辅助工具来确定同种抗体的来源。KEL基因分型结果显示，先证者为KEL6/6纯合子，而她的第二任伴侣为KEL*7/7纯合子。