Schönitzer D
Infusionsther Klin Ernahr. 1987 Apr;14 Suppl 2:3-9.
The frequency and clinical relevance of anti-Kell antibodies is reported based upon 80,509 antibody screenings in pregnant women over a period of 15 years. The pedigrees of two families involved in Kell-incompatibilities illustrate the sometimes tragic outcome of these pregnancies. Seven Kell-incompatibilities in the course of 134 pregnancies in 43 women with anti-Kell antibodies have been serologically verified. Three led to stillbirths, one to neurologic defects, another to jaundice without permanent clinical consequences and two babies had to undergo exchange transfusions but are healthy today. The Kell-selected transfusion strategy practised in our center was derived from our observations on the mode of sensitization. Protection against Kell-sensitization in cases of ABO-incompatible mother-child constellations, as well as possible protective effects of Rh-prophylaxis are discussed. Failure to recognize the problem or delay in serologic diagnosis are the most serious problems facing the Kell-incompatible pregnancy.
基于15年间对80509名孕妇进行的抗体筛查，报告了抗凯尔抗体的发生率及临床相关性。两个涉及凯尔血型不合的家族谱系说明了这些妊娠有时会产生悲剧性后果。在43名携带抗凯尔抗体的女性的134次妊娠过程中，有7例凯尔血型不合已通过血清学得到证实。其中3例导致死产，1例导致神经缺陷，另1例导致黄疸但无永久性临床后果，还有2名婴儿不得不接受换血治疗，但如今健康。我们中心实施的凯尔血型选择输血策略源自我们对致敏方式的观察。讨论了在ABO血型不合的母婴组合中预防凯尔致敏的措施，以及Rh预防可能产生的保护作用。未能认识到问题或血清学诊断延迟是凯尔血型不合妊娠面临的最严重问题。
