Zurada Joanna M, Kriegel David, Davis Ira C
Columbia University College of Physicians and Surgeons, New York, New York, USA.
J Am Acad Dermatol. 2006 Dec;55(6):1024-31. doi: 10.1016/j.jaad.2006.03.022. Epub 2006 Sep 18.
Hypertrophic scars represent an abnormal, exaggerated healing response after skin injury. In addition to cosmetic concern, scars may cause pain, pruritus, contractures, and other functional impairments. Therapeutic modalities include topical medications, intralesional corticosteroids, laser therapy, and cryosurgery. Topical therapies, in particular, have become increasingly popular because of their ease of use, comfort, noninvasiveness, and relatively low cost. This review will discuss the properties and effectiveness of these agents, including pressure therapy, silicone gel sheeting and ointment, polyurethane dressing, onion extract, imiquimod 5% cream, and vitamins A and E in the prevention and treatment of hypertrophic scars.
肥厚性瘢痕是皮肤损伤后异常、过度的愈合反应。除了美观问题外，瘢痕还可能引起疼痛、瘙痒、挛缩及其他功能障碍。治疗方法包括外用药物、病灶内注射皮质类固醇、激光治疗和冷冻手术。特别是外用疗法，因其使用方便、舒适、无创且成本相对较低，已变得越来越受欢迎。本综述将讨论这些药物的特性和有效性，包括压力疗法、硅胶片和软膏、聚氨酯敷料、洋葱提取物、5%咪喹莫特乳膏以及维生素A和E在预防和治疗肥厚性瘢痕方面的作用。
