Semaan Maroun T, Megerian Cliff A
Department of Otolaryngology and Head and Neck Surgery, University Hospitals of Cleveland, Case Western Reserve University, LKS 4500, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
Otolaryngol Clin North Am. 2006 Dec;39(6):1143-59. doi: 10.1016/j.otc.2006.08.003.
The pathogenesis of middle ear cholesteatoma continues to be highly debated. In recent years, there has been a substantial improvement in the understanding of the pathophysiology of this disease. This chapter provides a summary of the history and evolution of cholesteatoma and a review of the recent literature that pertains to the pathophysiology of congenital and acquired cholesteatoma. An emphasis is placed on the mechanism of osteolysis and the factors predictive of aggressiveness and recidivism.
中耳胆脂瘤的发病机制仍存在激烈争论。近年来，对该疾病病理生理学的认识有了显著提高。本章概述了胆脂瘤的历史和演变，并综述了近期与先天性和后天性胆脂瘤病理生理学相关的文献。重点关注骨吸收机制以及侵袭性和复发的预测因素。
