Khoroshilova I P, Ilatovskaia L V, Bordiugova G G, Gakhramanov F S
Vestn Oftalmol. 1991 Jan-Feb;107(1):12-6.
Specific features in the pathogenesis of ocular burns with a solution of an organic product, epichlorohydrin, are analyzed. Abnormalities in the vascular system anterior portion were revealed, related to the toxic effect of the agent on tissue vessels and to enhanced permeability and involvement of not only the cornea, but (and even more so) of the iris, where necrotic changes and hemorrhages eventuating in iris atrophy were detectable. Contrykal (hordox) therapy promoted a drastic inhibition of leukocytic and lymphocytic migration into burnt tissue, this resulting in a month in the formation of gentle cicatricial tissue with negligible residual inflammatory infiltration in the burn wound. Iris changes still persisted, since the drug appeared to have no effect on this process.
分析了用有机产品环氧氯丙烷溶液导致眼烧伤发病机制中的特定特征。发现前部血管系统存在异常，这与该制剂对组织血管的毒性作用以及通透性增强有关，不仅角膜受累，而且（甚至更严重的是）虹膜也受累，在虹膜处可检测到坏死变化和出血，最终导致虹膜萎缩。抗血纤溶芳酸（抑肽酶）疗法极大地抑制了白细胞和淋巴细胞向烧伤组织的迁移，这使得在一个月内形成了轻度瘢痕组织，烧伤创面的残余炎症浸润可忽略不计。虹膜变化仍然存在，因为该药物似乎对此过程没有影响。
