Perrier Stephane, Darakhshan Froogh, Hajduch Eric
Division of Molecular Physiology, MSI/WTB Complex, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
FEBS Lett. 2006 Nov 27;580(27):6289-94. doi: 10.1016/j.febslet.2006.10.061. Epub 2006 Nov 3.
Interleukin-1 receptor antagonist (IL-1ra) has been shown to play a crucial role in the prevention of various inflammatory diseases. There is also convincing evidence that IL-1ra is able to counteract inflammatory effects of IL-1 members implicated in insulin resistance and diabetes. However, the use of knock-out animal models provides evidence to the contrary and the role of IL-1ra in obesity-linked anomalies remains controversial. This minireview gets an insight into recent findings on the implication of IL-1ra and its gene polymorphism in diabetes and obesity, discusses the potential dual effects of IL-1ra observed in different models, and comments on future directions.
白细胞介素-1受体拮抗剂（IL-1ra）已被证明在预防各种炎症性疾病中起关键作用。也有令人信服的证据表明，IL-1ra能够抵消与胰岛素抵抗和糖尿病相关的IL-1家族成员的炎症作用。然而，基因敲除动物模型的研究结果却与此相反，IL-1ra在肥胖相关异常中的作用仍存在争议。本综述深入探讨了IL-1ra及其基因多态性在糖尿病和肥胖中的最新研究发现，讨论了在不同模型中观察到的IL-1ra的潜在双重作用，并对未来的研究方向进行了评论。
