Josephs Keith A, Whitwell Jennifer L, Dickson Dennis W, Boeve Bradley F, Knopman David S, Petersen Ronald C, Parisi Joseph E, Jack Clifford R
Department of Neurology (Movement Disorders), Mayo Clinic, Rochester, MN 55905, USA.
Neurobiol Aging. 2008 Feb;29(2):280-9. doi: 10.1016/j.neurobiolaging.2006.09.019. Epub 2006 Nov 13.
The aim of this study was to compare the patterns of grey and white matter atrophy on MRI in autopsy confirmed progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and to determine whether the patterns vary depending on the clinical syndrome. Voxel-based morphometry was used to compare patterns of atrophy in 13 PSP and 11 CBD subjects and 24 controls. PSP and CBD subjects were also subdivided into those with a dominant dementia or extrapyramidal syndrome. PSP subjects showed brainstem atrophy with involvement of the cortex and underlying white matter. Frontoparietal grey and subcortical grey matter atrophy occurred in CBD. When subdivided, PSP subjects with an extrapyramidal syndrome had more brainstem atrophy and less cortical atrophy than CBD subjects with an extrapyramidal syndrome. PSP subjects with a dementia syndrome had more subcortical white matter atrophy than CBD subjects with a dementia syndrome. These results show regional differences between PSP and CBD that are useful in predicting the underlying pathology, and help to shed light on the in vivo distribution of regional atrophy in PSP and CBD.
本研究的目的是比较经尸检确诊的进行性核上性麻痹（PSP）和皮质基底节变性（CBD）患者MRI上灰质和白质萎缩的模式，并确定这些模式是否因临床综合征而异。采用基于体素的形态测量法比较了13例PSP患者、11例CBD患者和24名对照者的萎缩模式。PSP和CBD患者还被细分为以痴呆或锥体外系综合征为主的患者。PSP患者表现为脑干萎缩，并累及皮质和深部白质。CBD患者出现额顶叶灰质和皮质下灰质萎缩。细分后，以锥体外系综合征为主的PSP患者比以锥体外系综合征为主的CBD患者脑干萎缩更明显，皮质萎缩更少。以痴呆综合征为主的PSP患者比以痴呆综合征为主的CBD患者皮质下白质萎缩更明显。这些结果显示了PSP和CBD之间的区域差异，有助于预测潜在的病理情况，并有助于阐明PSP和CBD中区域萎缩的活体分布情况。
