Whitwell Jennifer L, Jack Clifford R, Senjem Matthew L, Josephs Keith A
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Neurology. 2006 Jan 10;66(1):102-4. doi: 10.1212/01.wnl.0000191395.69438.12.
The authors used voxel-based morphometry to compare the patterns of brain atrophy in two variants of pathologically confirmed frontotemporal lobar degeneration (FTLD): FTLD with motor neuron disease (FTLD-MND) and FTLD with ubiquitin-only-immunoreactive neuronal changes (FTLD-U). Patterns of atrophy were distinct and different from each other. A localized pattern of frontal lobe atrophy was found in FTLD-MND with a more widespread pattern of atrophy affecting the frontal and temporal lobes in FTLD-U.
作者使用基于体素的形态测量法，比较了两种经病理证实的额颞叶痴呆（FTLD）变体中的脑萎缩模式：伴运动神经元病的额颞叶痴呆（FTLD-MND）和仅具有泛素免疫反应性神经元变化的额颞叶痴呆（FTLD-U）。萎缩模式彼此不同且有明显差异。在FTLD-MND中发现额叶局限性萎缩模式，而在FTLD-U中则有更广泛的萎缩模式，累及额叶和颞叶。
