Tang X
Institute of Medicinal Biotechnology, Beijing.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1990 Dec;12(6):391-5.
Thirty-three chinese medicinal herbs reputed by ancient chinese folklore to have anti-infective properties were extracted. The extracts and their compounds were tested for inhibitory activity against the human immunodeficiency virus RT in vitro. 8 of the 33 extracts were found to be active. Of these, MBAA9045 was studied in greater depth. We found that it was a noncompetitive inhibitor against HIV-RT. The concentration of MBAA9045 reducing HIV-RT activity by 50% (IC50) was 22 mumol/L. Chinese medicinal herbs appear to be a rich source of potentially useful materials for the treatment of human immunodeficiency virus infection.
对33种中国古代民间传说中具有抗感染特性的中草药进行了提取。对提取物及其化合物进行了体外抗人类免疫缺陷病毒逆转录酶（HIV-RT）抑制活性测试。33种提取物中有8种具有活性。其中，对MBAA9045进行了更深入的研究。我们发现它是一种针对HIV-RT的非竞争性抑制剂。使HIV-RT活性降低50%（IC50）的MBAA9045浓度为22微摩尔/升。中草药似乎是治疗人类免疫缺陷病毒感染潜在有用物质的丰富来源。
