Liu Zhao-Mei, Yang Yi-Shu, Wang Xiao-Li, Wen Rui-Xing
College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China.
Zhongguo Zhong Yao Za Zhi. 2006 Nov;31(21):1753-8.
This paper summarized the recent 6 years' progress of anti-HIV compounds and traditional Chinese medicines by searching international network and reviewing the domestic and foreign literature. Traditional Chinese medicinal appeared to be a rich source of potentially useful materials for the treatment of human immunodeficiency virus infection. Some of them are much more potent in anti-HIV activity. And some components extracted from the herbs are even more tonic than the crude herb medicines. It has been proved that some active components such as alkaloids, proteins, flavonoids, quercetin, terpene, lignanoid are able to work on anti-HIV. People should pay more attention to the study of traditional Chinese medicine and the leading compounds on anti-HIV/AIDS in the clinic and in the laboratory. So searching for high efficacy and low toxicity anti-HIV drug from traditional Chinese medicine is an important and prospective research direction in the future.
本文通过检索国际网络并查阅国内外文献，总结了近6年来抗HIV化合物和中药的研究进展。中药似乎是治疗人类免疫缺陷病毒感染潜在有用物质的丰富来源。其中一些在抗HIV活性方面更具效力。从草药中提取的一些成分甚至比生草药更具滋补作用。已证明一些活性成分如生物碱、蛋白质、黄酮类、槲皮素、萜类、木脂素具有抗HIV作用。人们应更加关注中药及临床和实验室中抗HIV/AIDS先导化合物的研究。因此，从中药中寻找高效低毒的抗HIV药物是未来一个重要且有前景的研究方向。
