约氏疟原虫环子孢子蛋白上的一个细胞毒性T淋巴细胞表位。
A CTL epitope on the circumsporozoite protein of P. yoelii.
作者信息
Weiss W R, Houghten R A, Good M F, Berzofsky J A, Miller L H, Hoffman S L
机构信息
Infectious Disease Department, Naval Medical Research Institute, Bethesda, MD 20814-5055.
出版信息
Bull World Health Organ. 1990;68 Suppl(Suppl):99-103.
Humans are infected with malaria by the bite of anophelene mosquitos carrying plasmodia sporozoites. These sporozoites pass quickly from the blood into hepatocytes, where they develop into mature liver-stage parasites over several days. The clinical stage of the illness begins only when the liver-stage parasites rupture into the bloodstream and erythrocytes are invaded. The pre-erythrocytic stages of malaria are inviting targets for vaccine development, because an effective immune response to these early stages would prevent symptomatic infections.
人类通过携带疟原虫子孢子的按蚊叮咬而感染疟疾。这些子孢子迅速从血液进入肝细胞，在那里它们会在几天内发育成成熟的肝期寄生虫。只有当肝期寄生虫破裂进入血液并侵入红细胞时，疾病的临床阶段才会开始。疟疾的红细胞前期是疫苗开发的诱人靶点，因为对这些早期阶段产生有效的免疫反应将预防有症状的感染。
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