与生物活性卡洛西菌素B相关的醌类化合物的构效关系研究
Structure-activity delineation of quinones related to the biologically active Calothrixin B.
作者信息
Bernardo Paul H, Chai Christina L L, Le Guen Maurice, Smith Geoffrey D, Waring Paul
机构信息
Department of Chemistry, Australian National University, Canberra, ACT 0200, Australia.
出版信息
Bioorg Med Chem Lett. 2007 Jan 1;17(1):82-5. doi: 10.1016/j.bmcl.2006.09.090. Epub 2006 Oct 4.
PMID:17098429
Abstract
Quinones such as Calothrixins A and B display a range of biological properties. As part of our ongoing studies to elucidate the mechanism of action of the Calothrixins, several related quinones were synthesized and tested for biological activity. The results of the structure-activity relationship (SAR) studies are reported here.
摘要
醌类化合物如Calothrixins A和B具有一系列生物学特性。作为我们正在进行的阐明Calothrixins作用机制研究的一部分，合成了几种相关的醌类化合物并测试了其生物活性。本文报道了构效关系（SAR）研究的结果。
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