Ramkumar Nagarajan, Nagarajan Rajagopal
School of Chemistry, University of Hyderabad , Hyderabad 500 046, India.
J Org Chem. 2014 Jan 17;79(2):736-41. doi: 10.1021/jo402593w. Epub 2014 Jan 6.
A direct route to the synthesis of biologically active ellipticine quinones, olivacine, and calothrixin B is described. The prominent key steps involved are Friedel-Crafts hydroxyalkylation followed by oxidation and directed ortho-lithiation reactions of readily available indole-2-carboxylate esters with appropriately substituted pyridine and quinoline carboxaldehydes.
本文描述了一条合成具有生物活性的玫瑰树碱醌、橄榄树碱和节旋藻毒素B的直接路线。所涉及的关键步骤包括傅克羟基烷基化反应，随后进行氧化反应，以及使容易获得的吲哚-2-羧酸酯与适当取代的吡啶和喹啉甲醛发生定向邻位锂化反应。
