Baudach A, Tille D, Schleusner A, Müller K, Gerisch A, Lobers W
Institut für Laboratoriumsdiagnostik, Klinikums Berlin-Buch.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1990;117(5):669-75.
As a result of investigations into the diagnostic validity of selected haematologic-morphological and clinical-chemical test factors of iron metabolism in the diagnosis of hypochromic anaemia, the examined test faktora are differently evaluated as individual parameters and in their combination. 1. Haematocrit (PCV) is equal to the determination of haemoglobin concentration as a search parameter. 2. The number of reticulocytes, copper and zinc as well as caeruloplasmin have a separating effect as individual parameters on the examined classes of iron deficiency and tumour and infect anaemia. 3. Iron has no value as a individual parameter. It is only in combination with TEBK and the haematologic test factors that is has a diagnostic value. 4. In contrast, ferritin as an individual parameter is of primary importance and should be used extensively in the laboratory diagnosis of hypochromic anaemia. 5. TEBK and transferrin may be supposed to be equal in their diagnostic value. 6. When used in combination, haemoglobin, MCV, TEBK, Transferrin, and ferritin have effective separating function. They permit hypochromic anaemia to be widely assigned to one or another kind of the examined classes.
通过对铁代谢的某些血液学形态学和临床化学检测指标在低色素性贫血诊断中的诊断效度进行研究，所检测的指标作为个体参数及其组合的评估结果各异。1. 血细胞比容（PCV）等同于作为筛查参数的血红蛋白浓度测定。2. 网织红细胞、铜、锌以及铜蓝蛋白作为个体参数，对所检测的缺铁性贫血、肿瘤性贫血和感染性贫血类别具有区分作用。3. 铁作为个体参数无诊断价值。仅与总铁结合力（TEBK）及血液学检测指标联合使用时才有诊断价值。4. 相比之下，铁蛋白作为个体参数至关重要，应广泛用于低色素性贫血的实验室诊断。5. 总铁结合力（TEBK）和转铁蛋白的诊断价值可能相当。6. 血红蛋白、平均红细胞体积（MCV）、总铁结合力（TEBK）、转铁蛋白和铁蛋白联合使用时具有有效的区分功能。它们可使低色素性贫血广泛归属于所检测的某一类贫血。
