Lallemand M, Villeneuve A, Belda J, Dubreuil P
Centre Hospitalier Universitaire Vétérinaire de St-Hyacinthe, 3200 Rue Sicotte, St-Hyacinthe, Québec J25 7C6, SC, Canada.
Vet Rec. 2006 Nov 11;159(20):672-6. doi: 10.1136/vr.159.20.672.
Ninety, seven- to 10-day-old calves were allocated to three groups of 30 and treated daily for seven days with either 100 microg/kg halofuginone hydrobromide or 2.5 mg/kg decoquinate orally or left untreated as controls. The levels of diarrhoea and dehydration were monitored daily for 28 days from the first day of treatment (day 0) and samples of faeces were collected on days 0, 7, 14, 21 and 28, to quantify the excretion of Cryptosporidium parvum oocysts. The calves were weighed on days 3 and 28. The treatments had no effect on the levels of diarrhoea or dehydration, the proportions of diarrhoeic calves or the proportions of calves shedding oocysts. However, unlike decoquinate, halofuginone significantly reduced the excretion of oocysts on day 7 (P<0.0001), and decoquinate increased the average daily weight gain of the calves (P=0.049).
90头7至10日龄的犊牛被分成3组，每组30头，连续7天每天口服100微克/千克氢溴酸常山酮或2.5毫克/千克地考喹酯，或不进行处理作为对照。从治疗第一天（第0天）起，每天监测腹泻和脱水情况，持续28天，并在第0、7、14、21和28天采集粪便样本，以量化微小隐孢子虫卵囊的排泄量。在第3天和第28天对犊牛进行称重。这些处理对腹泻或脱水程度、腹泻犊牛比例或排出卵囊的犊牛比例均无影响。然而，与地考喹酯不同，氢溴酸常山酮在第7天显著减少了卵囊排泄量（P<0.0001），且地考喹酯增加了犊牛的平均日增重（P=0.049）。
