Cruz Dinna N, Ocampo Catalina, Brendolan Alessandra, Menara Giuliano, Corradi Valentina, de Cal Massimo, Polanco Natalia, Kuang Dingwei, Nalesso Federico, Crepaldi Carlo, Ronco Claudio
Department of Nephrology, San Bortolo Hospital, Vicenza, Italy.
Contrib Nephrol. 2007;154:97-102. doi: 10.1159/000096817.
Vascular access in hemodialysis is a major point of concern in the management of chronic patients. Although arteriovenous fistula remains as the access of first choice, tunneled central venous catheters are still commonly used. Infection remains the principal cause of catheter dysfunction or loss. Many protocols have been used in order to prevent exit site infections and bacteremia. We describe our experience with the use of sodium hypochlorite, an electrolytic chloroxidizer used as a topical disinfectant. It has been shown to be active against a broad spectrum of potential pathogens and has other specific advantages compared to other cleansing agents, including its non-toxic, non-irritating nature and its low cost. We conclude that sodium hypochlorite solution in different concentrations (10 and 50%) is effective in preventing exit site infections and bacteremia associated with tunneled central venous catheters in chronic hemodialysis patients.
血液透析中的血管通路是慢性患者管理中的一个主要关注点。尽管动静脉内瘘仍是首选通路，但隧道式中心静脉导管仍被广泛使用。感染仍然是导管功能障碍或丢失的主要原因。为了预防出口部位感染和菌血症，人们采用了许多方案。我们描述了使用次氯酸钠（一种用作局部消毒剂的电解氯氧化剂）的经验。已证明它对多种潜在病原体具有活性，并且与其他清洁剂相比具有其他特定优势，包括其无毒、无刺激性以及低成本。我们得出结论，不同浓度（10%和50%）的次氯酸钠溶液可有效预防慢性血液透析患者隧道式中心静脉导管相关的出口部位感染和菌血症。
