Tock Lian, Prado Wagner L, Caranti Danielle A, Cristofalo Dejaldo M J, Lederman Henrique, Fisberg Mauro, Siqueira Kãli O, Stella Sérgio G, Antunes Hanna K, Cintra Isa P, Tufik Sérgio, de Mello Marco Túlio, Dâmaso Ana R
Federal University of São Paulo, Paulista Medicine School, UNIFESP, EPM, São Paulo, Brazil.
Eur J Gastroenterol Hepatol. 2006 Dec;18(12):1241-5. doi: 10.1097/01.meg.0000243872.86949.95.
Despite the increasing prevalence of nonalcoholic fatty liver disease, its pathogenesis and clinical significance remain poorly defined and there is no ideal treatment.
The aim of this study was to assess the short-term (12-week) multidisciplinary therapy on visceral adiposity and nonalcoholic fatty liver disease control.
We evaluated and compared the distribution of visceral adiposity and nonalcoholic fatty liver disease, by ultrasonography, in 73 post-puberty obese participants (17.01+/-1.6 years old; body mass index 36.54+/-2.86 kg/m), submitted to a multidisciplinary treatment without medications, at the beginning and after 12 weeks of intervention. Descriptive and one-way analysis of variance, and paired t-test were performed.
The results indicated that after intervention the adolescents had a significant reduction in visceral adiposity (4.05+/-1.55 to 3.37+/-1.44) and nonalcoholic fatty liver disease prevalence (from 52 to 29% on the right side and from 48 to 29% on the left side). It is a positive result because nonalcoholic fatty liver disease can progress to cirrhosis, even in children and adolescents.
The short-term treatment suggests a profound impact on the control of obesity-related co-morbidities in young people.
尽管非酒精性脂肪性肝病的患病率不断上升，但其发病机制和临床意义仍未明确界定，且尚无理想的治疗方法。
本研究旨在评估短期（12周）多学科治疗对内脏肥胖和非酒精性脂肪性肝病控制的效果。
我们通过超声检查评估并比较了73名青春期后肥胖参与者（17.01±1.6岁；体重指数36.54±2.86kg/m）在干预开始时和干预12周后的内脏肥胖分布及非酒精性脂肪性肝病情况。进行了描述性分析、单因素方差分析和配对t检验。
结果表明，干预后青少年的内脏肥胖显著降低（从4.05±1.55降至3.37±1.44），非酒精性脂肪性肝病患病率也降低（右侧从52%降至29%，左侧从48%降至29%）。这是一个积极的结果，因为即使在儿童和青少年中，非酒精性脂肪性肝病也可能进展为肝硬化。
短期治疗对控制年轻人肥胖相关的合并症有深远影响。
