Maziarz E Peter, Stachowski Mark J, Liu X Michael, Mosack Linda, Davis Ann, Musante Connie, Heckathorn David
Bausch & Lomb, Inc., Rochester, NY 14603, USA.
Eye Contact Lens. 2006 Dec;32(6):300-7. doi: 10.1097/01.icl.0000224365.51872.6c.
To investigate the sorption of oleic acid, oleic acid methyl ester, and cholesterol on currently marketed silicone hydrogel contact lenses.
Two liquid chromatography methods were developed and used to analyze lens extracts from continuous-wear and daily-wear modalities from asymptomatic silicone hydrogel contact lens wearers.
Of the three probed compounds, cholesterol is the most prevalently sorbed, at levels ranging from below the limit of quantitation (<1.50 microg per lens) to approximately 37.0 microg per lens. Oleic acid and oleic acid methyl ester were found to exist at levels below the limit of quantitation (<1.50 microg per lens). In general, there appears to be no significant difference between the amounts of cholesterol sorbed on the continuous-wear PureVision and daily-wear PureVision lenses evaluated.
The quantities of lipid sorbed to continuous-wear PureVision lenses are significantly different from those previously reported by other authors in a similarly conducted experiment. This difference suggests that any hypothesis of silicone hydrogel lenses based on these previous lipid data should be reconsidered.
研究油酸、油酸甲酯和胆固醇在目前市售硅水凝胶隐形眼镜上的吸附情况。
开发了两种液相色谱方法，用于分析无症状硅水凝胶隐形眼镜佩戴者连续佩戴和日戴模式下的镜片提取物。
在所检测的三种化合物中，胆固醇的吸附最为普遍，含量范围从低于定量限（每片镜片<1.50微克）到每片镜片约37.0微克。发现油酸和油酸甲酯的含量低于定量限（每片镜片<1.50微克）。总体而言，在评估的连续佩戴的PureVision镜片和日戴的PureVision镜片上吸附的胆固醇量之间似乎没有显著差异。
连续佩戴的PureVision镜片吸附的脂质数量与其他作者在类似实验中先前报道的结果有显著差异。这种差异表明，基于这些先前脂质数据的任何关于硅水凝胶镜片的假设都应重新考虑。
