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妊娠和哺乳期对大鼠肝脏中一些与葡萄糖代谢相关酶活性的影响。

The effects of pregnancy and lactation on the activities in rat liver of some enzymes associated with glucose metabolism.

作者信息

Smith R W

出版信息

Biochim Biophys Acta. 1975 Nov 10;411(1):22-9. doi: 10.1016/0304-4165(75)90281-0.

DOI:10.1016/0304-4165(75)90281-0
PMID:170998
Abstract
  1. The ratio of the combined activities of hexokinase (EC 2.7.1.1) and glucokinase (EC 2.7.1.2) to the activity of glucose-6-phosphatase (EC 3.1.3.9) changed in favour of the glycolytic enzymes during pregnancy and at peak lactation. 2. There were no important changes in the ratio of the activity of phosphofructokinase (EC 2.7.1.11) to that of fructose diphosphatase (EC 3.1.3.11). 3. The ratio of the activity of pyruvate kinase (EC 2.7.1.40) to the combined activities of phosphoenolpyruvate carboxylase (EE 4.1.1.32) and pyruvate carboxylase (EC 6.4.1.1) changed in favour of the glycolytic enzyme during pregnancy and at peak lactation, but changed in favour of the gluconeogenic enzymes immediately after parturition. 4. These changes are considered in relation to the changes in food intake and hormonal status that occur during pregnancy and lactation.
摘要
  1. 在孕期和泌乳高峰期,己糖激酶(EC 2.7.1.1)和葡萄糖激酶(EC 2.7.1.2)的联合活性与葡萄糖-6-磷酸酶(EC 3.1.3.9)活性的比值发生变化,有利于糖酵解酶。2. 磷酸果糖激酶(EC 2.7.1.11)与果糖二磷酸酶(EC 3.1.3.11)的活性比值没有重要变化。3. 丙酮酸激酶(EC 2.7.1.40)与磷酸烯醇式丙酮酸羧化酶(EE 4.1.1.32)和丙酮酸羧化酶(EC 6.4.1.1)联合活性的比值在孕期和泌乳高峰期有利于糖酵解酶,但在分娩后立即有利于糖异生酶。4. 这些变化与孕期和哺乳期食物摄入量及激素状态的变化有关。

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The effects of pregnancy and lactation on the activities in rat liver of some enzymes associated with glucose metabolism.妊娠和哺乳期对大鼠肝脏中一些与葡萄糖代谢相关酶活性的影响。
Biochim Biophys Acta. 1975 Nov 10;411(1):22-9. doi: 10.1016/0304-4165(75)90281-0.
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Changes in the proportion of acetyl-CoA carboxylase in the active form in rat liver. Effect of starvation, lactation and weaning.大鼠肝脏中活性形式的乙酰辅酶A羧化酶比例的变化。饥饿、哺乳和断奶的影响。
Biochem J. 1982 Jun 15;204(3):757-64. doi: 10.1042/bj2040757.
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