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[急性缺氧时大鼠肾皮质糖异生酶的活性]

[Activity of gluconeogenetic enzymes of rat kidney cortex during acute hypoxia].

作者信息

Postupaev V V, Litonian Z M

出版信息

Biull Eksp Biol Med. 1978 Apr;85(4):415-6.

PMID:207372
Abstract

The activities of gluconeogenic enzymes of the rat kidney cortex was studied after exposure to lowered atmospheric pressure (200 mm Hg) for 3 hours. The hypoxic stress was found to cause an increase in the activities of phosphoenolpyruvate carboxykinase and alanine aminotransferase, but failed to affect significantly the activities of fructose-1,6-diphosphatase, glucose-6-phosphatase, and aspartate aminotranspherase. The ratio of glucose-6-phosphatase/hexokinase activities was increased under these conditions.

摘要

在将大鼠肾皮质暴露于低气压(200毫米汞柱)3小时后,对其糖异生酶的活性进行了研究。发现低氧应激会导致磷酸烯醇式丙酮酸羧激酶和丙氨酸转氨酶的活性增加,但对果糖-1,6-二磷酸酶、葡萄糖-6-磷酸酶和天冬氨酸转氨酶的活性没有显著影响。在这些条件下,葡萄糖-6-磷酸酶/己糖激酶活性的比值增加。

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