Larbcharoensub Noppadol, Tubtong Nattha, Praneetvatakul Veeraphol, Pongtippan Atcharaporn, Leopairat Juvady, Sirikulchayanonta Vorachai
Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 2006 Sep;89(9):1536-41.
Lymphoepithelial carcinoma is a relatively uncommon malignant tumor of the salivary gland demonstrating malignant epithelial cells with dense lymphoid stroma. The authors report three cases of lymphoepithelial carcinoma associated with Epstein-Barr virus of the right parotid gland with clinically presenting as painless, gradual enlargement of the preauricular mass. The histopathologic examination of the parotid gland is characterized by malignant epithelial cells with dense lymphoid stroma. Immunohistochemical stains show positive reactivity to cytokeratin and p53 in malignant epithelial cells. In situ hybridization of the Epstein-Barr virus-encoded Ribonucleic acid shows positivity in malignant epithelial cells. Clinical and pathologic features with relevant literatures are discussed. These are the first reported cases of primary parotid lymphoepithelial carcinoma associated with Epstein-Barr virus infection in Thailand and Southeast Asia.
淋巴上皮癌是一种相对罕见的唾液腺恶性肿瘤，其特征为恶性上皮细胞伴有密集的淋巴间质。作者报告了3例与爱泼斯坦-巴尔病毒相关的右腮腺淋巴上皮癌病例，临床表现为耳前肿块无痛性、渐进性肿大。腮腺的组织病理学检查显示为伴有密集淋巴间质的恶性上皮细胞。免疫组织化学染色显示恶性上皮细胞对细胞角蛋白和p53呈阳性反应。爱泼斯坦-巴尔病毒编码的核糖核酸原位杂交显示恶性上皮细胞呈阳性。本文讨论了相关临床和病理特征及文献。这些是泰国和东南亚首次报道的与爱泼斯坦-巴尔病毒感染相关的原发性腮腺淋巴上皮癌病例。
