Kim Leung, Kimmel Alan R
Department of Biological Sciences, Florida International University, Miami, FL 33199, USA.
Curr Drug Targets. 2006 Nov;7(11):1411-9. doi: 10.2174/1389450110607011411.
GSK3 is a multifunctional protein kinase that is pivotal for the regulation of metabolism, the cytoskeleton, and gene expression. Multicellular eukaryotes utilize GSK3 as a molecular switch to specify distinct cell fates, but also to organize these cells spatially within the developing organism. We discuss the central role of GSK3 in control of the Wnt, Hedgehog, cAMP (in Dictyostelium), and other signaling pathways, but also focus on significant new evidence that GSK3 is required to establish cell polarity.
糖原合成酶激酶3（GSK3）是一种多功能蛋白激酶，对代谢、细胞骨架和基因表达的调节至关重要。多细胞真核生物利用GSK3作为分子开关来确定不同的细胞命运，同时也在发育中的生物体中对这些细胞进行空间组织。我们讨论了GSK3在控制Wnt、Hedgehog、cAMP（在盘基网柄菌中）和其他信号通路中的核心作用，同时也关注GSK3对于建立细胞极性的重要新证据。
