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植物病毒蛋白的磷酸化:分析方法与生物学功能

Phosphorylation of plant virus proteins: Analysis methods and biological functions.

作者信息

Zhuang Xinjian, Guo Xiao, Gu Tianxiao, Xu Xiaowei, Qin Lang, Xu Kai, He Zhen, Zhang Kun

机构信息

Department of Plant Protection, College of Horticulture and Plant Protection, Yangzhou University, Yangzhou, China.

Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, China.

出版信息

Front Microbiol. 2022 Jul 26;13:935735. doi: 10.3389/fmicb.2022.935735. eCollection 2022.

DOI:10.3389/fmicb.2022.935735
PMID:35958157
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9360750/
Abstract

Phosphorylation is one of the most extensively investigated post-translational modifications that orchestrate a variety of cellular signal transduction processes. The phosphorylation of virus-encoded proteins plays an important regulatory role in the infection cycle of such viruses in plants. In recent years, molecular mechanisms underlying the phosphorylation of plant viral proteins have been widely studied. Based on recent publications, our study summarizes the phosphorylation analyses of plant viral proteins and categorizes their effects on biological functions according to the viral life cycle. This review provides a theoretical basis for elucidating the molecular mechanisms of viral infection. Furthermore, it deepens our understanding of the biological functions of phosphorylation in the interactions between plants and viruses.

摘要

磷酸化是研究最为广泛的翻译后修饰之一,它协调着多种细胞信号转导过程。病毒编码蛋白的磷酸化在这类病毒侵染植物的循环过程中发挥着重要的调控作用。近年来,植物病毒蛋白磷酸化的分子机制得到了广泛研究。基于近期的文献,我们的研究总结了植物病毒蛋白的磷酸化分析,并根据病毒生命周期对其生物学功能的影响进行了分类。这篇综述为阐明病毒感染的分子机制提供了理论基础。此外,它加深了我们对植物与病毒相互作用中磷酸化生物学功能的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b0/9360750/e27d0d3611be/fmicb-13-935735-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b0/9360750/c7831ac99900/fmicb-13-935735-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b0/9360750/66682f615dc2/fmicb-13-935735-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b0/9360750/98484425bba0/fmicb-13-935735-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b0/9360750/e27d0d3611be/fmicb-13-935735-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b0/9360750/c7831ac99900/fmicb-13-935735-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b0/9360750/66682f615dc2/fmicb-13-935735-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b0/9360750/98484425bba0/fmicb-13-935735-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/54b0/9360750/e27d0d3611be/fmicb-13-935735-g004.jpg

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本文引用的文献

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Plant Cell. 2022 Jul 30;34(8):3110-3127. doi: 10.1093/plcell/koac143.
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Phosphorylated viral protein evades plant immunity through interfering the function of RNA-binding protein.磷酸化病毒蛋白通过干扰 RNA 结合蛋白的功能来逃避植物免疫。
PLoS Pathog. 2022 Mar 16;18(3):e1010412. doi: 10.1371/journal.ppat.1010412. eCollection 2022 Mar.
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Coat proteins of necroviruses target 14-3-3a to subvert MAPKKKα-mediated antiviral immunity in plants.
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Nat Commun. 2022 Feb 7;13(1):716. doi: 10.1038/s41467-022-28395-5.
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