Zartler E R, Shapiro M J
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Maryland, Baltimore, 20 Penn Street, Baltimore, MD 21201, USA.
Curr Pharm Des. 2006;12(31):3963-72. doi: 10.2174/138161206778743619.
Protein NMR as a screening tool in drug discovery has become prominent within the past ten years. Advances in protein manipulation, whether by biological means (labeling) or physical means (NMR), have created a powerful method that is able to observe ligand-target interactions in solution.
在过去十年中，蛋白质核磁共振作为药物发现中的一种筛选工具已变得十分突出。蛋白质操作方面的进展，无论是通过生物学手段（标记）还是物理手段（核磁共振），都创造了一种强大的方法，能够在溶液中观察配体与靶点的相互作用。
