Loughnan M S
Department of Ophthalmology, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.
Aust N Z J Ophthalmol. 1991 Feb;19(1):65-9. doi: 10.1111/j.1442-9071.1991.tb00324.x.
Recently many soluble growth factors capable of influencing neovascularisation (angiogenesis) have been isolated and molecularly cloned. As such they are now available in a highly purified and active form. One or several of these already quite well known molecules may be of importance in the control of ocular neovascularisation. This article reviews what is presently known about growth factor control of neovascularisation with particular emphasis on both the eye and those factors that have already been molecularly cloned. In addition several recently reported inhibitors of neovascularisation are discussed. Such research is of particular interest to the ophthalmologist as knowledge gained in this area may allow for the use of both growth factors as well as growth factor inhibitors in the management of several ocular diseases involving neovascularisation.
最近，许多能够影响新血管形成（血管生成）的可溶性生长因子已被分离并进行分子克隆。因此，它们现在可以以高度纯化和活性的形式获得。这些已经相当知名的分子中的一种或几种可能在控制眼部新血管形成中具有重要意义。本文综述了目前已知的关于生长因子对新血管形成的控制，特别强调了眼睛以及那些已经进行分子克隆的因子。此外，还讨论了几种最近报道的新血管形成抑制剂。这类研究对眼科医生特别有吸引力，因为在这一领域获得的知识可能使生长因子以及生长因子抑制剂用于治疗几种涉及新血管形成的眼部疾病。
