Brown R A, Weiss J B
Experimental Pathology Dept, Royal National Orthopaedics Hospital, Stanmore, Middlesex.
Ann Rheum Dis. 1988 Nov;47(11):881-5. doi: 10.1136/ard.47.11.881.
In osteoarthritis angiogenesis is involved in the reinitiation of cartilage growth and mineralisation. A number of heparin binding protein growth factors have been proposed as angiogenic factors, but none of them is specific for microvessel cells. Another factor which is specific for microvessel cells, is of low molecular weight and non-profit has been called endothelial cell stimulating angiogenic factor (ESAF). ESAF has been found in significantly increased amounts in sera and synovial fluids of osteoarthritic patients and dogs. In addition to its angiogenic activity ESAF is able to activate neutral prometalloproteinases and to reactive the active enzyme-inhibitor complex. The implication of these observations in the pathogenesis of osteoarthritis is discussed.
在骨关节炎中，血管生成参与软骨生长和矿化的重新启动。一些肝素结合蛋白生长因子已被提出作为血管生成因子，但它们中没有一个对微血管细胞具有特异性。另一个对微血管细胞具有特异性、分子量低且无活性的因子被称为内皮细胞刺激血管生成因子（ESAF）。已发现骨关节炎患者和犬类的血清及滑液中ESAF的含量显著增加。除了其血管生成活性外，ESAF还能够激活中性前金属蛋白酶并使活性酶 - 抑制剂复合物重新活化。本文讨论了这些观察结果在骨关节炎发病机制中的意义。
