钙离子对小鼠输精管神经肌肉传递影响的电生理分析。
An electrophysiological analysis of the effect of Ca ions on neuromuscular transmission in the mouse vas deferens.
作者信息
Bennett M R, Florin T
出版信息
Br J Pharmacol. 1975 Sep;55(1):97-104. doi: 10.1111/j.1476-5381.1975.tb07616.x.
Abstract
1 A study has been made of the effects of changing the external calcium concentration [Ca]0 and the external magnesium concentration [Mg]0 on the synaptic potential due to noradrenaline release. 2 When [Ca]0 was varied in the range 0.7 to 1.8 mM, the synaptic potential increased as about the second power of [Ca]0. 3 Increasing [Mg]0 depressed the synaptic potential; however, variation of [Ca]0 in the presence of high [Mg]0 did not significantly change the power relationship between the synaptic potential and [Ca]0. 4 The facilitated increase in the synaptic potential during short trains of impulses at different frequencies was quantitatively predicted on the assumption that each impulse leaves residual Ca ions bound to release receptors in the nerve terminal.
摘要
- 已经研究了改变细胞外钙浓度[Ca]0和细胞外镁浓度[Mg]0对去甲肾上腺素释放引起的突触电位的影响。2. 当[Ca]0在0.7至1.8 mM范围内变化时，突触电位约随[Ca]0的二次幂增加。3. 增加[Mg]0会抑制突触电位；然而，在高[Mg]0存在的情况下改变[Ca]0并不会显著改变突触电位与[Ca]0之间的幂关系。4. 在不同频率的短串脉冲期间突触电位的促进性增加是基于每个脉冲都会使残留钙离子结合到神经末梢中的释放受体上这一假设进行定量预测的。
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本文引用的文献
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EFFECT OF CALCIUM AND MAGNESIUM ON NEUROMUSCULAR TRANSMISSION IN THE HYPOGASTRIC NERVE-VAS DEFERENS PREPARATION OF THE GUINEA-PIG.钙和镁对豚鼠腹下神经 - 输精管标本神经肌肉传递的影响
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Movements of labelled calcium in squid giant axons.标记钙在枪乌贼巨大轴突中的移动。
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The nature of the antagonism between calcium and magnesium ions at the neuromuscular junction.神经肌肉接头处钙离子与镁离子之间拮抗作用的本质。
J Physiol. 1957 Oct 30;138(3):434-44. doi: 10.1113/jphysiol.1957.sp005860.
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A further study of the statistical composition on the end-plate potential.关于终板电位统计构成的进一步研究。
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Depolarization and calcium entry in squid giant axons.枪乌贼巨大轴突中的去极化和钙内流。
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