在神经肌肉接头处锶离子和钙离子对递质释放的激活作用。
Activation of transmitter release by strontium and calcium ions at the neuromuscular junction.
作者信息
Meiri U, Rahamimoff R
出版信息
J Physiol. 1971 Jul;215(3):709-26. doi: 10.1113/jphysiol.1971.sp009493.
Abstract
- The interaction between Ca and Sr ions on quantal transmitter release at the frog neuromuscular junction was studied, using conventional electrophysiological techniques.2. While Ca ions always activate transmitter release, the activating action of Sr ions depends on the Ca ion concentration in the medium; at low [Ca], strontium ions enhance the release, but at higher [Ca] they inhibit it. It is postulated that there is a [Ca] at which Sr ions do not affect transmitter liberation.3. When Sr activates release, its effect and the effect of Ca add in a more than linear fashion.4. Magnesium ions inhibit the release induced by Sr.5. The results can be explained by assuming that Ca and Sr act on the same site, at some stage of the process of quantal transmitter release. The affinity of both ions towards the sites is approximately the same, but the effectiveness of Sr is much smaller.
摘要
运用传统电生理技术，研究了蛙神经肌肉接头处钙离子和锶离子对量子化递质释放的相互作用。
虽然钙离子总是激活递质释放，但锶离子的激活作用取决于介质中钙离子的浓度；在低[Ca]时，锶离子增强释放，但在较高[Ca]时则抑制释放。据推测，存在一个[Ca]值，此时锶离子不影响递质释放。
当锶激活释放时，其作用与钙离子的作用以超线性方式相加。
镁离子抑制由锶诱导的释放。
这些结果可以通过假设钙离子和锶离子在量子化递质释放过程的某个阶段作用于同一位点来解释。两种离子对这些位点的亲和力大致相同，但锶的有效性要小得多。
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