伴有肝转移的甲胎蛋白产生型早期胃癌：三例报告
alpha Fetoprotein producing early gastric cancer with liver metastasis: report of three cases.
作者信息
Chang Y C, Nagasue N, Abe S, Kohno H, Kumar D D, Nakamura T
机构信息
Second Department of Surgery, Shimane Medical University, Izumo, Japan.
出版信息
Gut. 1991 May;32(5):542-5. doi: 10.1136/gut.32.5.542.
Abstract
Three cases of alpha fetoprotein producing early gastric cancer are presented. Liver metastases occurred in all patients shortly after curative gastrectomy and all died within two years. The incidence of liver metastasis was significantly higher than that in alpha fetoprotein negative early gastric carcinoma (p less than 0.001). The incidences of lymph node metastasis and invasion in lymph vessels and veins were also substantially higher in this group of patients. Two radical hepatic resections, including extended right lobectomy, were performed on one patient but the tumour recurred immediately.
摘要
本文报告了3例产生甲胎蛋白的早期胃癌病例。所有患者在根治性胃切除术后不久均发生肝转移，且均在两年内死亡。肝转移的发生率显著高于甲胎蛋白阴性的早期胃癌（p<0.001）。该组患者的淋巴结转移以及淋巴管和静脉侵犯的发生率也明显更高。对1例患者进行了两次根治性肝切除术，包括扩大右叶切除术，但肿瘤立即复发。
相似文献
1
alpha Fetoprotein producing early gastric cancer with liver metastasis: report of three cases.伴有肝转移的甲胎蛋白产生型早期胃癌：三例报告
Gut. 1991 May;32(5):542-5. doi: 10.1136/gut.32.5.542.
2
Clinicopathologic features and long-term results of alpha-fetoprotein-producing gastric cancer.
Am J Gastroenterol. 1990 Nov;85(11):1480-5.
3
Resection of liver metastases from an alpha-fetoprotein-producing gastric cancer.切除来自产生甲胎蛋白的胃癌的肝转移瘤。
J Nippon Med Sch. 2005 Feb;72(1):66-70. doi: 10.1272/jnms.72.66.
4
Successfully treated metachronous liver metastasis of alpha-fetoprotein-producing early gastric cancer: case report.成功治疗产甲胎蛋白早期胃癌的异时性肝转移：病例报告
Hepatogastroenterology. 2004 May-Jun;51(57):919-20.
5
Hepatoid adenocarcinoma of the stomach: report of five cases and review of the literature.胃肝样腺癌：5例报告并文献复习
Acta Gastroenterol Belg. 2006 Jul-Sep;69(3):330-7.
6
Clinicopathologic features of gastric cancers producing alpha-fetoprotein.产生甲胎蛋白的胃癌的临床病理特征
Dig Surg. 2002;19(5):359-65; discussion 365. doi: 10.1159/000065838.
7
High level of serum AFP is an independent negative prognostic factor in gastric cancer.血清甲胎蛋白水平升高是胃癌的一个独立负面预后因素。
Int J Biol Markers. 2015 Nov 11;30(4):e387-93. doi: 10.5301/jbm.5000167.
8
Resection of liver metastasis from alpha-fetoprotein-producing early gastric cancer: report of a case.甲胎蛋白产生型早期胃癌肝转移灶切除术：病例报告
Surg Today. 1997;27(6):563-6. doi: 10.1007/BF02385813.
9
The potential for the development of liver metastasis from alpha-fetoprotein-producing human gastric carcinomas in nude mice.裸鼠中产生甲胎蛋白的人胃癌发生肝转移的可能性。
Jpn J Clin Oncol. 1992 Oct;22(5):303-7.
10
AFP-producing gastric carcinoma: multivariate analysis of prognostic factors in 270 patients.产甲胎蛋白胃癌：270例患者预后因素的多变量分析
Oncology. 2003;65(2):95-101. doi: 10.1159/000072332.
引用本文的文献
1
Targeted therapy of cancer stem cells: inhibition of mTOR in pre-clinical and clinical research.癌症干细胞的靶向治疗：mTOR 在临床前和临床研究中的抑制作用。
Cell Death Dis. 2024 Sep 30;15(9):696. doi: 10.1038/s41419-024-07077-8.
2
Human epidermal growth factor 2 overexpressed alpha-fetoprotein-producing-gastric cancer.人表皮生长因子2过表达的产甲胎蛋白胃癌
Discov Oncol. 2023 Jun 24;14(1):111. doi: 10.1007/s12672-023-00731-1.
3
Metachronous Liver Metastasis from Alpha-Fetoprotein-Producing Gastric Cancer Successfully Treated with Capecitabine/Oxaliplatin Combination Chemotherapy.采用卡培他滨/奥沙利铂联合化疗成功治疗甲胎蛋白产生型胃癌的异时性肝转移
Case Rep Surg. 2022 Aug 23;2022:2700394. doi: 10.1155/2022/2700394. eCollection 2022.
4
Both the serum AFP test and AFP/GPC3/SALL4 immunohistochemistry are beneficial for predicting the prognosis of gastric adenocarcinoma.血清 AFP 检测和 AFP/GPC3/SALL4 免疫组化对预测胃腺癌的预后均有帮助。
BMC Gastroenterol. 2021 Oct 27;21(1):408. doi: 10.1186/s12876-021-01986-0.
5
The prognosis of hepatoid adenocarcinoma of the stomach: a propensity score-based analysis.胃肝样腺癌的预后：基于倾向评分的分析。
BMC Cancer. 2020 Jul 17;20(1):671. doi: 10.1186/s12885-020-07031-9.
6
PIVKA-II is a useful tool for diagnostic characterization of ultrasound-detected liver nodules in cirrhotic patients.异常凝血酶原是用于对肝硬化患者超声检测出的肝脏结节进行诊断特征描述的有用工具。
Medicine (Baltimore). 2017 Jun;96(26):e7266. doi: 10.1097/MD.0000000000007266.
7
Clinicopathologic and prognostic characteristics of alpha-fetoprotein-producing gastric cancer.产甲胎蛋白胃癌的临床病理及预后特征
Oncotarget. 2017 Apr 4;8(14):23817-23830. doi: 10.18632/oncotarget.15909.
8
Regional Arterial Infusion Chemotherapy improves the Pathological Response rate for advanced gastric cancer with Short-term Neoadjuvant Chemotherapy.区域动脉灌注化疗联合短期新辅助化疗可提高进展期胃癌的病理缓解率。
Sci Rep. 2015 Dec 1;5:17516. doi: 10.1038/srep17516.
9
Clinicopathological characteristics and prognosis of alpha-fetoprotein positive gastric cancer in Chinese patients.中国患者甲胎蛋白阳性胃癌的临床病理特征及预后
Int J Clin Exp Pathol. 2015 Jun 1;8(6):6345-55. eCollection 2015.
10
A case of acinar cell carcinoma of the pancreas that formed extensive tumor thrombus of the portal vein.一例形成广泛门静脉瘤栓的胰腺腺泡细胞癌。
Clin J Gastroenterol. 2009 Apr;2(2):96-102. doi: 10.1007/s12328-008-0044-x. Epub 2008 Dec 5.
本文引用的文献
1
2
Early gastric cancer: results in a general hospital in Japan.早期胃癌：日本一家综合医院的研究结果
World J Surg. 1984 Jun;8(3):308-14. doi: 10.1007/BF01655060.
3
Increased alpha-fetoprotein concentration in association with ileal adenocarcinoma complicating Crohn's disease.甲胎蛋白浓度升高与克罗恩病并发回肠腺癌相关。
J Clin Pathol. 1984 Mar;37(3):293-7. doi: 10.1136/jcp.37.3.293.
4
[Existence of alpha feto protein during gastric-origin secondary cancer of the liver].[原发性肝癌胃转移癌中甲胎蛋白的存在情况]
Presse Med (1893). 1970 Jun 6;78(28):1277-8.
5
Alpha-fetoprotein and carcinoembryonic antigen in a case of gastric carcinoma metastatic to the liver.
Am J Dig Dis. 1973 Jun;18(6):517-20. doi: 10.1007/BF01076605.
6
Alpha-fetoprotein in a patient with gastric carcinoma metastatic to the liver.一名发生肝转移的胃癌患者的甲胎蛋白
N Engl J Med. 1971 Nov 4;285(19):1058-9. doi: 10.1056/NEJM197111042851905.
7
Prognostic factors of early gastric cancer--results of long-term follow-up and analysis of recurrent cases.
Jpn J Surg. 1987 Jul;17(4):248-55. doi: 10.1007/BF02470696.
8
Factors influencing the postoperative course 113 patients with early gastric cancer.
Jpn J Clin Oncol. 1986 Dec;16(4):325-34.
9
[Characterization of human AFP producing stomach cancer xenotransplanted in nude mice and effect of a conjugate of MMC and antibody to human AFP on this tumor].
Nihon Shokakibyo Gakkai Zasshi. 1985 Jan;82(1):18-27.
10
[Clinicopathological study of AFP producing gastric cancer--significance of AFP in gastric cancer].【产甲胎蛋白胃癌的临床病理研究——甲胎蛋白在胃癌中的意义】
Nihon Geka Gakkai Zasshi. 1987 Jun;88(6):696-700.
Zotero 插件