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Effects of poliovirus replication on undifferentiated and differentiated monocytic U937 cells: comparative studies with human macrophages.

作者信息

López-Guerrero J A, Cabañas C, Bernabeu C, Fresno M, Alonso M A

机构信息

Centro de Biología Molecular, Universidad Autónoma, CSIC, Madrid, Spain.

出版信息

Intervirology. 1991;32(3):137-48. doi: 10.1159/000150194.

DOI:10.1159/000150194
PMID:1710210
Abstract

Poliovirus infection of either undifferentiated or differentiated U937 cells produced a decrease in the percentage of cells positive for the surface expression of the CD4, CD11c, CD14, or 8E11 antigens. The number of 4F2 surface molecules per cell increased in infected normal U937 cells, but was unaffected in differentiated cells. The level of O2- production in infected differentiated U937 cells was approximately 50% of that found when not infected. Finally, poliovirus RNA levels and infectious particle production were similar in either cell type.

摘要

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