Mai Hoa, Champion Laure, Ouali Nacera, Hertig Alexandre, Peraldi Marie-Noelle, Glotz Denis, Rondeau Eric, Costa Marie-Alyette, Snanoudj Renaud, Benoit Gérard, Charpentier Bernard, Durrbach Antoine
Nephrology Unit, Bicetre Hospital Le Kremlin Bicetre, Paris, France.
Transplantation. 2006 Nov 15;82(9):1163-7. doi: 10.1097/01.tp.0000239188.27153.23.
Mycotic arteritis and/or aneurysms are infrequent complications of renal transplantation. They are mostly secondary to bacterial infection and rarely to Candida albicans. We report four cases of mycotic arteritis due to C. albicans after renal transplantation but which have been inoculated during organ harvesting or conservation.
In all the four cases corresponding to two independent donors, C. albicans was isolated few days later in the systematic culture of the conservative liquid. We also review the clinical features and outcomes of 13 cases previously reported in the literature.
In two cases, the diagnosis of fungal arteritis was confirmed only during autopsy after the patient's death due to massive bleeding. In the other two cases, the diagnosis was made on the arterial section of the anastomotic wall after detransplantation for massive bleeding for arterial leakage although an immediate antifungal treatment with fluconazole and caspofungin was given and was found to be inefficient.
This is a serious complication of renal transplantation because it leads to graft loss in the majority of the cases and even to death in a few cases despite an efficient and rapid treatment. Routine fungal cultures of preservation media are important for early diagnosis and timely surgical interventions are life-saving.
