Shyu Jia-Fwu, Chen Tien-Hua, Shyr Yi-Ming, Su Cheng-Hsi, Wu Chew-Wun, Lui Wing-Yiu
Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan, R.O.C.
World J Surg. 2006 Dec;30(12):2204-7; discussion 2208-9. doi: 10.1007/s00268-005-0330-4.
To prevent or minimize leakage after simple closure of giant perforated peptic ulcers in critically ill elderly patients, we conducted a clinical study using gastric body partition to prevent upstream gastric juice and food from passing through the sutured ulcer.
Ten critically ill elderly patients with giant (> 2.5 m) perforated peptic ulcer were included in the study of gastric body partition.
The patients' mean age was 78.2 years and mean delay in treatment was 95.6 hours. None of the 10 patients had major complications after operation, although minor leakage of the sutured ulcer occurred in 4 patients. Only one patient presented with recurrent anastomotic ulcer and one patient died 28 days after surgery.
Gastric body partition and gastrojejunostomy, in addition to simple closure of a giant perforated peptic ulcer, could be a quick, easy, and potentially effective alternative to avoid or at least to minimize leakage of the sutured ulcer. Moreover, gastric body partition, unlike antral partition, might not necessarily increase risks of hypergastrinemia and marginal ulcer.
为预防或尽量减少危重症老年患者单纯缝合巨大穿孔性消化性溃疡后的渗漏,我们开展了一项临床研究,采用胃体分隔术来防止上游胃液和食物通过缝合的溃疡。
10例患有巨大(>2.5cm)穿孔性消化性溃疡的危重症老年患者纳入胃体分隔术研究。
患者平均年龄78.2岁,平均治疗延迟时间95.6小时。10例患者术后均未出现严重并发症,尽管4例患者缝合的溃疡出现轻微渗漏。仅1例患者出现复发性吻合口溃疡,1例患者术后28天死亡。
除单纯缝合巨大穿孔性消化性溃疡外,胃体分隔术和胃空肠吻合术可能是一种快速、简便且潜在有效的替代方法,可避免或至少尽量减少缝合溃疡的渗漏。此外,与胃窦分隔术不同,胃体分隔术不一定会增加高胃泌素血症和边缘性溃疡的风险。