[Liver microsome monooxygenase activity in rats under the effects of organochlorine and organophosphorus pesticides and different nutrition background].

The influence of acute and chronic intoxication with a mixture of lindane and trichlorometaphos-3 on monooxygenases of rat liver was studied in rats insufficiently provided with lysine and vitamins A, C and E. It has been found that in the presence of poly-nutrient insufficiency monooxygenase induction develops more rapidly and to a greater extent than in the presence of balanced nutrition. Chronic intoxication with the pesticide mixture leads to monooxygenase system induction under both regimens of nutrition. It has been noted that in most cases monooxygenase induction during intoxication in the presence of poly-nutrient insufficiency is attended by an increase of the relative mass of the liver. A possible role of this phenomenon has been considered.