Patra R C, Swarup D, Sharma M C, Naresh R
Environmental Medicine Laboratory, Division of Medicine, Indian Veterinary Research Institute, Izatnagar 243 122, UP, India.
J Vet Med A Physiol Pathol Clin Med. 2006 Dec;53(10):511-7. doi: 10.1111/j.1439-0442.2006.00868.x.
The present investigation was carried out to assess the trace mineral profile in blood and hair from cows environmentally exposed to lead and cadmium and to examine if these toxic heavy metals in blood and hair could affect blood copper, cobalt, zinc and iron concentrations and their accumulation in hair. Respective blood and tail hair samples were collected from adult cows above 3 years, reared in different industrial localities. Samples were also collected from urban areas with small industrial units (n = 55) and areas supposed to be free from pollution. The concomitant exposure of animals to both the heavy metal pollutants was not recorded in either of the industrial or urban locality. Blood lead was significantly (P < 0.01) correlated with blood copper (r = -0.339), cobalt (r = -0.224) and iron (r = -0.497). The increasing blood lead concentrations, irrespective of area of collection of samples, was associated with declining blood copper and iron, and cows with blood lead level above 0.60 mug/ml had significantly (P < 0.05) lower blood copper and iron. The higher blood lead but not cadmium significantly influenced the accumulation of lead (r = 0.323, P < 0.01) and cadmium (r = 0.204, P < 0.01) in hair possibly leading to significantly (P < 0.05) higher accumulation of both lead and cadmium in hair from cattle around lead-zinc smelters and closed lead-cum-operational zinc smelter, where blood cadmium level was comparable with that from unpolluted area. Concentration of zinc (r = 0.237, P < 0.01) and iron (r = 0.183, P < 0.01) but not copper and cobalt in tail hair was significantly influenced by their respective blood concentration. Both the hair lead and cadmium had a significant (P < 0.01) positive correlation with hair copper (r = 0.234, 0.294), zinc (r = 0.489, 0.775), and iron (r = 0.385, 0.643) concentrations. Thus, it is concluded from the present study that the higher blood lead concentrations in cattle irrespective of locality/industrial operations areas affected trace elements profile in blood and hair.
本研究旨在评估环境中暴露于铅和镉的奶牛血液和毛发中的微量矿物质概况，并研究血液和毛发中的这些有毒重金属是否会影响血液中铜、钴、锌和铁的浓度及其在毛发中的积累。从3岁以上的成年奶牛采集相应的血液和尾毛样本，这些奶牛饲养在不同的工业地区。样本还采集自小型工业单位的城市地区（n = 55）以及被认为无污染的地区。在工业或城市地区均未记录到动物同时暴露于两种重金属污染物的情况。血铅与血铜（r = -0.339）、钴（r = -0.224）和铁（r = -0.497）显著相关（P < 0.01）。无论样本采集区域如何，血铅浓度的增加都与血铜和铁的下降有关，血铅水平高于0.60微克/毫升的奶牛血铜和铁显著降低（P < 0.05）。较高的血铅而非镉显著影响毛发中铅（r = 0.323，P < 0.01）和镉（r = 0.204，P < 0.01）的积累，这可能导致铅锌冶炼厂和关闭的铅兼运营锌冶炼厂周围的牛毛发中铅和镉的积累显著增加（P < 0.05），而这些地方的血镉水平与未受污染地区相当。尾毛中锌（r = 0.237，P < 0.01）和铁（r = 0.183，P < 0.01）的浓度而非铜和钴的浓度受其各自血液浓度的显著影响。毛发中的铅和镉与毛发铜（r = 0.234，0.294）、锌（r = 0.489，0.775）和铁（r = 0.385，0.643）的浓度均呈显著正相关（P < 0.01）。因此，本研究得出结论，无论地区/工业作业区域如何，奶牛血液中较高的血铅浓度都会影响血液和毛发中的微量元素概况。
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