Pilkington Karen, Boshnakova Anelia, Richardson Janet
Research Council for Complementary Medicine, London, UK.
Complement Ther Med. 2006 Dec;14(4):268-81. doi: 10.1016/j.ctim.2006.01.003. Epub 2006 Feb 28.
To review the development of the evidence on the herbal remedy, St John's wort (SJW) (Hypericum perforatum), in the treatment of depression.
Searches of major biomedical and specialist databases including EMBASE, MEDLINE, PsycINFO, AMED and HerbMed were conducted. Searches aimed to identify quantitative research (systematic reviews and meta-analyses) and relevant qualitative studies. Data were extracted systematically.
Systematic reviews have been published regularly over the past 10 years. Methodology has varied resulting in differing estimates of effectiveness but overall findings have been positive when compared with placebo for mild to moderate depression. Recent reviews have focused on adverse effects and interactions. One qualitative study focusing on SJW in depression was retrieved.
SJW has received intensive and continued attention since initial indications of its potential effectiveness for depression. The focus appears to be moving from effectiveness to safety but the patient's perspective has received less attention and may prove a valuable avenue for future studies.
回顾草药圣约翰草（SJW，贯叶连翘）治疗抑郁症的证据发展情况。
检索了包括EMBASE、MEDLINE、PsycINFO、AMED和HerbMed在内的主要生物医学和专业数据库。检索旨在识别定量研究（系统评价和荟萃分析）以及相关的定性研究。数据进行了系统提取。
在过去10年中定期发表了系统评价。方法各不相同，导致对有效性的估计有所差异，但与安慰剂相比，总体结果对轻至中度抑郁症呈阳性。最近的评价集中在不良反应和相互作用上。检索到一项关于SJW治疗抑郁症的定性研究。
自从最初显示出其治疗抑郁症的潜在有效性以来，SJW受到了持续的密切关注。重点似乎正从有效性转向安全性，但患者的观点受到的关注较少，可能是未来研究的一个有价值的方向。
