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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Turski W A, Lachowicz L

II Department of Biochemistry, Institute of Physiology and Biochemistry, School of Medicine, Lódź, Poland.

Int J Biochem. 1991;23(3):317-21. doi: 10.1016/0020-711x(91)90113-2.

Nuclear fraction of cortex and synaptosomal fraction of hippocampus of rat brain were preincubated with ATP and different, "second messengers" as well as some "classical" neurotransmitters and then incubated with Glp6[125I]Tyr8SP6-11 (JP). 2. It was found that different neurotransmitters and especially "second messengers" might be involved in the activation or inhibition of peptidase I and II. 3. Activation of different protein kinases results in substantial modulation of degradation of JP (SP C-terminal fragment). 4. The data confirm that products of one peptidase might be inhibitors of the second peptidase acting on JP, although the second enzyme might be affected additionally in conditions activating different protein kinase systems.

将大鼠大脑皮层的细胞核部分以及海马体的突触体部分与ATP、不同的“第二信使”以及一些“经典”神经递质进行预孵育，然后与Glp6[125I]Tyr8SP6 - 11（JP）一起孵育。2. 发现不同的神经递质，尤其是“第二信使”，可能参与肽酶I和II的激活或抑制。3. 不同蛋白激酶的激活导致JP（SP C末端片段）降解的显著调节。4. 数据证实，一种肽酶的产物可能是作用于JP的第二种肽酶的抑制剂，尽管在激活不同蛋白激酶系统的条件下，第二种酶可能会受到额外影响。

Turski W A, Lachowicz L

II Department of Biochemistry, Institute of Physiology and Biochemistry, School of Medicine, Lódź, Poland.

Int J Biochem. 1991;23(3):317-21. doi: 10.1016/0020-711x(91)90113-2.

Nuclear fraction of cortex and synaptosomal fraction of hippocampus of rat brain were preincubated with ATP and different, "second messengers" as well as some "classical" neurotransmitters and then incubated with Glp6[125I]Tyr8SP6-11 (JP). 2. It was found that different neurotransmitters and especially "second messengers" might be involved in the activation or inhibition of peptidase I and II. 3. Activation of different protein kinases results in substantial modulation of degradation of JP (SP C-terminal fragment). 4. The data confirm that products of one peptidase might be inhibitors of the second peptidase acting on JP, although the second enzyme might be affected additionally in conditions activating different protein kinase systems.

将大鼠大脑皮层的细胞核部分以及海马体的突触体部分与ATP、不同的“第二信使”以及一些“经典”神经递质进行预孵育，然后与Glp6[125I]Tyr8SP6 - 11（JP）一起孵育。2. 发现不同的神经递质，尤其是“第二信使”，可能参与肽酶I和II的激活或抑制。3. 不同蛋白激酶的激活导致JP（SP C末端片段）降解的显著调节。4. 数据证实，一种肽酶的产物可能是作用于JP的第二种肽酶的抑制剂，尽管在激活不同蛋白激酶系统的条件下，第二种酶可能会受到额外影响。