Koltas Ismail S, Yucebilgic Guzide, Bilgin Ramazan, Parsak Cem K, Sakman Gurhan
Department of Parasitology, Faculty of Medicine, University of Cukurova 01330, Balcali, Adana,Turkey.
Saudi Med J. 2006 Nov;27(11):1703-5.
To investigate the changes of serum malondialdehyde (MDA) level for the oxidative stress hypothesis in patients with cystic echinococcosis (CE).
The study was conducted on patients with CE before the surgical treatment. Anti-Echinococcus granulosus antibodies were determined by serological method. We assayed MDA activities measured of 57 subjects and matched in 45 healthy controls. This study took place in the Faculty of Medicine, University of Cukurova, Balcali Hospital in Adana, Turkey, between March 2004 and October 2005.
The mean +/- SD of MDA levels of patients with CE was 6.70 +/- 1.66 and healthy controls was 2.53 +/- 0.43. The difference between MDA levels of patients and controls was statistically significant (p<0.001).
The high infection/control ratio of MDA concentration and the significant correlation strongly indicate the occurrence of oxidative stress and lipid peroxidation as a mechanism of tissue damage in cases of CE. Our study highlights the usefulness of serum markers to investigate complex pathological situations, including distinct forms of chronic liver inflammation associated with CE.
探讨囊性棘球蚴病（CE）患者氧化应激假说中血清丙二醛（MDA）水平的变化。
对手术治疗前的CE患者进行研究。采用血清学方法检测抗细粒棘球绦虫抗体。我们测定了57例受试者的MDA活性，并与45例健康对照进行匹配。本研究于2004年3月至2005年10月在土耳其阿达纳的库库罗瓦大学医学院巴尔卡利医院进行。
CE患者MDA水平的平均值±标准差为6.70±1.66，健康对照为2.53±0.43。患者与对照的MDA水平差异具有统计学意义（p<0.001）。
MDA浓度的高感染/对照比值及显著相关性强烈表明氧化应激和脂质过氧化的发生是CE病例中组织损伤的一种机制。我们的研究强调了血清标志物在研究复杂病理情况（包括与CE相关的不同形式的慢性肝脏炎症）中的有用性。
