Wipf Peter, Maciejewski John P
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Org Lett. 2008 Oct 2;10(19):4383-6. doi: 10.1021/ol801860s. Epub 2008 Sep 10.
Reductive cyclization of epoxides tethered to substituted anilines and aminopyridines in the presence of 3 mol % of titanocene dichloride and stoichiometric manganese metal promotes a radical annulation to form 3,3-disubstituted indolines and azaindolines.
在3摩尔%二氯二茂钛和化学计量的锰金属存在下,与取代苯胺和氨基吡啶相连的环氧化合物的还原环化促进自由基环化反应,生成3,3-二取代吲哚啉和氮杂吲哚啉。