Tsunoi Shinji, Maruoka Yoshiaki, Suzuki Itaru, Shibata Ikuya
Research Center for Environmental Preservation, Osaka University, 2-4 Yamadaoka, Suita, Osaka 565-0871, Japan.
Org Lett. 2015 Aug 21;17(16):4010-3. doi: 10.1021/acs.orglett.5b01905. Epub 2015 Aug 6.
The catalytic synthesis of γ-butyrolactams was established via [3 + 2]-cycloaddition of cyclopropanes with isocyanates. An organotin iodide ate complex, MgBr(+)Bu2SnBrI2, was employed as an effective catalyst. Simple cyclopropanes that lack aryl or vinyl substituents were useful precursors. Even acyl cyclopropanes were applicable. The hybrid characteristics of a tin complex, acidic MgBr(+) with nucleophilic tin iodide, was responsible for the catalytic reaction.
通过环丙烷与异氰酸酯的[3 + 2]环加成反应实现了γ-丁内酰胺的催化合成。一种有机锡碘酸盐络合物MgBr(+)Bu2SnBrI2被用作有效催化剂。缺乏芳基或乙烯基取代基的简单环丙烷是有用的前体。甚至酰基环丙烷也适用。锡络合物的混合特性，即酸性的MgBr(+)与亲核性的碘化锡，是催化反应的原因。
