海马沟宽度及空洞：阿尔茨海默病患者与非痴呆老年受试者的比较
Hippocampal sulcus width and cavities: comparison between patients with Alzheimer disease and nondemented elderly subjects.
作者信息
Bastos-Leite A J, van Waesberghe J H, Oen A L, van der Flier W M, Scheltens P, Barkhof F
机构信息
Department of Radiology and Image Analysis Center, VU University Medical Center, Amsterdam, the Netherlands.
出版信息
AJNR Am J Neuroradiol. 2006 Nov-Dec;27(10):2141-5.
BACKGROUND AND PURPOSE
The hippocampal fissure is a fetal sulcus that, except for its most medial part (the superficial hippocampal sulcus), is normally obliterated. Hippocampal cavities are residual cysts attributable to lack of hippocampal fissure obliteration. We hypothesized that either hippocampal sulcus enlargement or an increase in number or size of hippocampal cavities could be associated with medial temporal lobe atrophy (MTA) occurring in Alzheimer disease.
METHODS
Two observers assessed the maximal hippocampal sulcus width by means of the fimbriosubicular distance at the anterior part of the hippocampal body; as well as the occurrence, number, and size of hippocampal cavities; and the visual rating score of MTA on magnified coronal high-resolution T1-weighted MR images of 21 patients with Alzheimer disease and 15 nondemented elderly controls.
RESULTS
Both observers found the maximal hippocampal sulcus width significantly larger in patients with Alzheimer disease than in controls (P < .0001). The interobserver averaged fimbriosubicular distance in patients with Alzheimer disease was 2.84 mm (SD = 0.94), approximately twice that of the corresponding distance in nondemented subjects (1.41 mm; SD, 0.58). Both observers found a significant correlation between the fimbriosubicular distance and MTA score (observer 1, r(s) = 0.71; observer 2, r(s) = 0.74; P < .0001). None of the observers found significant differences between patients with Alzheimer disease and nondemented subjects with respect to occurrence, number, or size of hippocampal cavities, nor did they find a significant correlation between the number or size of hippocampal cavities and MTA. Interobserver agreement ranged from moderate to very good.
CONCLUSION
Enlargement of the hippocampal sulcus, assessed by the fimbriosubicular distance, is associated with MTA in Alzheimer disease, but enlargement of the hippocampal cavities is not.
背景与目的
海马裂是一条胎儿期脑沟，除其最内侧部分（浅表海马沟）外，通常会消失。海马腔是由于海马裂未消失而残留的囊肿。我们推测，海马沟增宽或海马腔数量或大小增加可能与阿尔茨海默病中发生的内侧颞叶萎缩（MTA）有关。
方法
两名观察者通过海马体前部的穹窿下托距离评估最大海马沟宽度；以及海马腔的发生情况、数量和大小；并在21例阿尔茨海默病患者和15名非痴呆老年对照的放大冠状高分辨率T1加权磁共振图像上对MTA进行视觉评分。
结果
两名观察者均发现，阿尔茨海默病患者的最大海马沟宽度显著大于对照组（P <.0001）。阿尔茨海默病患者观察者间平均穹窿下托距离为2.84 mm（标准差 = 0.94），约为非痴呆受试者相应距离（1.41 mm；标准差，0.58）的两倍。两名观察者均发现穹窿下托距离与MTA评分之间存在显著相关性（观察者1，rs = 0.71；观察者2，rs = 0.74；P <.0001）。两名观察者均未发现阿尔茨海默病患者与非痴呆受试者在海马腔的发生情况、数量或大小方面存在显著差异，也未发现海马腔的数量或大小与MTA之间存在显著相关性。观察者间一致性从中度到非常好。
结论
通过穹窿下托距离评估的海马沟增宽与阿尔茨海默病中的MTA相关，但海马腔增宽则不然。
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