1-（N-氯乙酰氨基）-烷基膦酸——膦肽的合成前体。

1-(N-chloroacetylamino)-alkylphosphonic acids - synthetic precursors of phosphonopeptides.

作者信息

Kudzin Z H, Depczyński R, Kudzin M H, Drabowicz J

机构信息

Institute of Chemistry, University of Łódź, Łódź, Poland.

出版信息

Amino Acids. 2008 Jan;34(1):163-8. doi: 10.1007/s00726-006-0462-3. Epub 2006 Nov 20.

DOI:10.1007/s00726-006-0462-3

PMID:17111101

Abstract

General procedures of N-chloroacetylation of the representative 1-aminoalkylphosphonic acids (Gly(P), Ala(P), Val(P), Pgly(P) and Phe(P)) are described. These 1-(N-chloroacetylamino)-alkylphosphonic acids were converted into the corresponding glycylphosphonodipeptides (Gly-AA(P)) and/or related N-alkylglycylphosphonodipeptides (Me(n)Gly-AA(P)) in the course of ammonolysis/aminolysis. Physico-chemical properties of synthesized 1-(N-chloroacetylamino)-alkylphosphonic acids and phosphonodipeptides are characterized.

摘要

描述了代表性的1-氨基烷基膦酸（甘氨酸（P）、丙氨酸（P）、缬氨酸（P）、磷酰甘氨酸（P）和苯丙氨酸（P））的N-氯乙酰化的一般程序。这些1-（N-氯乙酰氨基）-烷基膦酸在氨解/胺解过程中转化为相应的甘氨酰膦二肽（甘氨酸-氨基酸（P））和/或相关的N-烷基甘氨酰膦二肽（Me(n)甘氨酸-氨基酸（P））。对合成的1-（N-氯乙酰氨基）-烷基膦酸和膦二肽的物理化学性质进行了表征。