Schwartz M S, Scott R M
Division of Neurosurgery, Albany Medical College, Albany, New York; and Department of Neurosurgery, The Children's Hospital, Division of Neurosurgery, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts.
Neurosurg Focus. 1998 Nov 15;5(5):e7.
The authors report the case of a 30-year-old woman who was a long-term intranasal cocaine abuser and who presented with transient ischemic attacks and multiple cerebral infarctions that were associated with moyamoya syndrome. The authors suggest that, because of its sympathomimetic effects, chronic cocaine use may promote intracranial arterial stenosis, distal ischemia, and subsequent formation of moyamoya-like vessels. The patient has remained clinically stable with no new episodes of stroke 6 years after undergoing "pial synangiosis" (modified encephaloduroarteriosynangiosis) to revascularize both hemispheres. Cocaine abuse may lead to moyamoya syndrome and may represent a chronic effect on the cerebral vasculature.
作者报告了一例30岁女性病例，该女性长期滥用鼻内可卡因，出现短暂性脑缺血发作和与烟雾病综合征相关的多发性脑梗死。作者认为，由于可卡因的拟交感神经作用，长期使用可卡因可能会促进颅内动脉狭窄、远端缺血以及随后烟雾状血管的形成。该患者在接受“软脑膜吻合术”（改良脑硬脑膜动脉吻合术）以使双侧半球血管重建6年后，临床症状保持稳定，未出现新的中风发作。可卡因滥用可能导致烟雾病综合征，并且可能是对脑血管系统的一种慢性影响。
