Morón I, Gallo M
Department of Experimental Psychology and Physiology of Behavior, University of Granada, Campus Cartuja, 18071 Granada, Spain.
Physiol Behav. 2007 Feb 28;90(2-3):308-17. doi: 10.1016/j.physbeh.2006.09.036. Epub 2006 Nov 15.
Neophobia is an innate response that can be defined as the reluctance to consume novel-tasting substances. The differential effect of previous aversive and nonaversive taste memory on a subsequent neophobic response was studied in young-adult (Experiment 1) and aged rats (Experiment 2). Surprising, a previous nonaversive taste experience eliminated the subsequent neophobic response to a solution of 1% sodium chloride (NaCl) in young-adult and aged rats. This result is interpreted as a generalization of the previous safe taste memory and the emotional responses that might be induced when a new taste is presented. However, a differential effect associated with aging was found for a previous aversive taste memory induced with a low dose of lithium chloride (0.15 M; 1% b.w.). While in young-adult rats this aversive taste memory did not change the neophobic response to an NaCl solution, in aged rats this memory potentiated the subsequent neophobic response to NaCl. This result is interpreted as an increase in the generalization of aversive taste memory and the emotional responses associated with aging.
新物恐惧症是一种先天反应，可定义为不愿食用新口味的物质。在年轻成年大鼠（实验1）和老年大鼠（实验2）中研究了先前的厌恶和非厌恶味觉记忆对随后新物恐惧反应的不同影响。令人惊讶的是，先前的非厌恶味觉体验消除了年轻成年大鼠和老年大鼠随后对1%氯化钠（NaCl）溶液的新物恐惧反应。这一结果被解释为先前安全味觉记忆以及呈现新口味时可能引发的情绪反应的泛化。然而，对于用低剂量氯化锂（0.15 M；1%体重）诱导的先前厌恶味觉记忆，发现了与衰老相关的差异效应。在年轻成年大鼠中，这种厌恶味觉记忆并未改变对NaCl溶液的新物恐惧反应，而在老年大鼠中，这种记忆增强了随后对NaCl的新物恐惧反应。这一结果被解释为厌恶味觉记忆的泛化增加以及与衰老相关的情绪反应增加。
