Boecker Maren, Buecheler Markus M, Schroeter Matthias L, Gauggel Siegfried
Department of Medical Psychology and Medical Sociology, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.
Behav Brain Res. 2007 Jan 25;176(2):259-66. doi: 10.1016/j.bbr.2006.10.009. Epub 2006 Nov 16.
Previous lesion and neuroimaging studies have shown that the frontal lobes play an important role in response inhibition. In the present study event-related functional near-infrared spectroscopy (NIRS) was applied to investigate cerebral blood oxygenation in the right and left prefrontal cortex (PFC) in 15 male participants during the performance of a stop-change paradigm. Data analysis showed stronger brain activation in the left and right PFC during successful and failed stopping of initiated responses in comparison to a condition without stopping. Changes in cerebral blood oxygenation were more pronounced in the right than in the left PFC. No substantial activation changes were found during successful or failed changing of initiated responses (response inhibition and subsequent response re-engagement). The findings indicate that NIRS is suitable for the functional identification of prefrontal activation during the inhibition of initiated responses and provide further support for the contribution of the PFC to response inhibition.
先前的损伤和神经影像学研究表明，额叶在反应抑制中起重要作用。在本研究中，运用事件相关功能近红外光谱技术（NIRS），对15名男性参与者在执行停止-改变范式期间左右前额叶皮层（PFC）的脑血氧合情况进行了研究。数据分析显示，与无停止条件相比，在成功和失败地停止已启动反应时，左右前额叶皮层均有更强的脑激活。右侧前额叶皮层的脑血氧合变化比左侧更明显。在成功或失败地改变已启动反应（反应抑制及随后的反应重新参与）过程中，未发现明显的激活变化。这些发现表明，NIRS适用于在抑制已启动反应期间对前额叶激活进行功能识别，并为前额叶皮层对反应抑制的作用提供了进一步支持。
