通过多通道近红外光谱技术检测在连线测验期间前额叶皮质的激活情况。
Activation of the prefrontal cortex during the Trail-Making Test detected with multichannel near-infrared spectroscopy.
作者信息
Shibuya-Tayoshi Sumiko, Sumitani Satsuki, Kikuchi Kumiko, Tanaka Tsunehiko, Tayoshi Shin'ya, Ueno Shu-Ichi, Ohmori Tetsuro
机构信息
Department of Psychiatry, Course of Integrated Brain Sciences, Institute of Health Bioscience, University of Tokushima Graduate School, Tokushima, Japan.
出版信息
Psychiatry Clin Neurosci. 2007 Dec;61(6):616-21. doi: 10.1111/j.1440-1819.2007.01727.x.
The Trail-Making Test (TMT) is a neuropsychological test for evaluating executive function, and the TMT Part B reflects more complex cognitive processes including cognitive set shifting. The prefrontal cortex (PFC) is thought to be involved in these cognitive processes. The purpose of the present paper was to investigate PFC activation during performance of the TMT Part A and Part B using multichannel near-infrared spectroscopy (NIRS). Subjects were 41 healthy right-handed volunteers. The hemodynamic changes in the PFC during the TMT were measured on a 22-channel NIRS machine. The subjects had a greater increase of oxygenated hemoglobin ([oxyHb]) during the TMT Part B than during Part A in the PFC. Twenty-seven out of the 41 subjects had a bilateral increase of [oxyHb] in the PFC during Part B according to laterality index. NIRS detected activation in the PFC during the performance of the TMT Part B and this PFC activation may reflect executive functions including cognitive set shifting involved in the TMT Part B.
连线测验（TMT）是一种用于评估执行功能的神经心理学测试，TMT B部分反映了更复杂的认知过程，包括认知定势转换。前额叶皮层（PFC）被认为参与了这些认知过程。本文的目的是使用多通道近红外光谱（NIRS）研究在进行TMT A部分和B部分时PFC的激活情况。受试者为41名健康的右利手志愿者。在一台22通道NIRS机器上测量了TMT过程中PFC的血流动力学变化。在PFC中，受试者在TMT B部分期间的氧合血红蛋白（[oxyHb]）增加量比在A部分期间更大。根据偏侧性指数，41名受试者中有27名在B部分期间PFC的[oxyHb]出现双侧增加。NIRS检测到在进行TMT B部分时PFC有激活，这种PFC激活可能反映了包括TMT B部分所涉及的认知定势转换在内的执行功能。
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