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大鼠嗜碱性白血病（RBL-2H3）细胞中免疫球蛋白E受体聚集诱导的钙信号和组胺分泌

Calcium signal and histamine secretion induced by aggregation of immunoglobulin E receptors in rat basophilic leukemia (RBL-2H3) cells.

作者信息

Maeyama K, Yagi S, Sasaki M, Sakurai E, Watanabe T

机构信息

Department of Pharmacology I, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Agents Actions Suppl. 1991;33:417-22. doi: 10.1007/978-3-0348-7309-3_32.

DOI:10.1007/978-3-0348-7309-3_32
PMID:1711276
Abstract

The changes in cytosolic Ca concentration in rat basophilic leukemia cells (RBL-2H3) were determined using a fluorescent Ca probe, fura-2, after aggregation of IgE receptors. By means of a superfusion system, both histamine secretion and changes in cytosolic Ca concentration were determined simultaneously. In addition, the microscopic observation revealed the oscillatory Ca signal after stimulation with an antigen.

摘要

在IgE受体聚集后，使用荧光钙探针fura-2测定大鼠嗜碱性白血病细胞（RBL-2H3）胞质钙浓度的变化。通过灌流系统，同时测定组胺分泌和胞质钙浓度的变化。此外，显微镜观察显示用抗原刺激后出现振荡性钙信号。

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