五肽胃泌素刺激完全离体的经血管灌注大鼠胃释放组胺及分泌胃酸。
Pentagastrin-stimulated histamine release and acid secretion from the totally isolated vascularly perfused rat stomach.
作者信息
Iwasa K, Sandvik A K, Waldum H L
机构信息
Department of Medicine, University Hospital, Trondheim, Norway.
出版信息
Agents Actions Suppl. 1991;33:429-34. doi: 10.1007/978-3-0348-7309-3_34.
PMID:1711278
Abstract
This study was performed to examine the effect of cAMP levels on histamine release in the isolated rat stomach. Pentagastrin-induced histamine release was unaffected by phosphodiesterase inhibition, and pentagastrin itself had no phosphodiesterase-like effect. The results support previous observations showing that histamine is likely to be the mediator of the acid secretagogue effect of (penta) gastrin.
摘要
本研究旨在检测环磷酸腺苷（cAMP）水平对离体大鼠胃中组胺释放的影响。五肽胃泌素诱导的组胺释放不受磷酸二酯酶抑制的影响，且五肽胃泌素本身没有类似磷酸二酯酶的作用。这些结果支持了先前的观察结果，表明组胺可能是（五肽）胃泌素酸分泌效应的介质。
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