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Pentagastrin-stimulated histamine release and acid secretion from the totally isolated vascularly perfused rat stomach.

作者信息

Iwasa K, Sandvik A K, Waldum H L

机构信息

Department of Medicine, University Hospital, Trondheim, Norway.

出版信息

Agents Actions Suppl. 1991;33:429-34. doi: 10.1007/978-3-0348-7309-3_34.

Abstract

This study was performed to examine the effect of cAMP levels on histamine release in the isolated rat stomach. Pentagastrin-induced histamine release was unaffected by phosphodiesterase inhibition, and pentagastrin itself had no phosphodiesterase-like effect. The results support previous observations showing that histamine is likely to be the mediator of the acid secretagogue effect of (penta) gastrin.

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