Mårvik R, Sandvik A K, Waldum H L
Dept of Surgery, Trondheim University Hospital, Norway.
Scand J Gastroenterol. 1997 Jan;32(1):2-5. doi: 10.3109/00365529709025055.
Gastrin has been shown to give an immediate and dose-dependent histamine release preceding acid secretion in the totally isolated, vascularly perfused rat stomach.
In the present study we prepared isolated, vascularly perfused stomachs taken from pigs and examined the effect of pentagastrin in a concentration of 520 pM on the histamine release to the vascular bed. Pentagastrin was given for three 5-min periods at 10-min intervals, and histamine was determined by a radioimmunoassay method.
Each pentagastrin dose resulted in stimulation of histamine release in the three pig stomachs examined. The various histamine concentrations increased to levels previously shown to stimulate aminopyrine accumulation in isolated pig parietal cells.
The present study shows for the first time that gastrin induces histamine release to the vascular bed in the pig, as previously shown for the rat and dog.
在完全分离、血管灌注的大鼠胃中，胃泌素已被证明在胃酸分泌之前能立即引起剂量依赖性的组胺释放。
在本研究中，我们制备了取自猪的分离、血管灌注胃，并研究了浓度为520 pM的五肽胃泌素对向血管床释放组胺的影响。五肽胃泌素以10分钟的间隔给药三个5分钟周期，组胺通过放射免疫分析法测定。
在所检查的三只猪胃中，每剂五肽胃泌素均导致组胺释放增加。各种组胺浓度增加到先前显示能刺激分离的猪壁细胞中氨基比林积累的水平。
本研究首次表明，胃泌素能像先前在大鼠和狗中所显示的那样，诱导猪向血管床释放组胺。
