Sano T, Yamane A, Tokura T, Miki H
Department of Ophthalmology, Kansai Medical University, Moriguchi, Japan.
Nippon Ganka Gakkai Zasshi. 1991 Feb;95(2):140-6.
Experimental tractional retinal detachments in rabbits' eyes was produced several weeks following aspiration of vitreous gels through a posterior small window of the eye wall. Histological examination showed that intravitreal proliferative tissues contained many fibroblasts, derived from the optic disc a small amount of migrated RPE, macrophages and other cells associated with proliferative tissues, Glial cells also grew especially at the epi-retina, causing shrinkage of the sensory retina. Vitreous neovascularization deriving from the retinal vessels was also found in these proliferative tissues. Our experimental data indicated that the extent of proliferative tissues mainly depend upon the amount of vitreous loss and vitreous hemorrhage, and the duration of retinal detachment. This experiment may be useful as an animal model of vitreous neovascularization.
通过眼壁后部小窗口抽吸玻璃体凝胶数周后，在兔眼中产生了实验性牵引性视网膜脱离。组织学检查显示，玻璃体内增殖组织含有许多成纤维细胞，这些成纤维细胞来源于视盘，有少量迁移的视网膜色素上皮（RPE）、巨噬细胞和与增殖组织相关的其他细胞，神经胶质细胞也生长，尤其是在视网膜表面，导致感觉视网膜萎缩。在这些增殖组织中还发现了源自视网膜血管的玻璃体新生血管。我们的实验数据表明，增殖组织的范围主要取决于玻璃体丢失量、玻璃体积血以及视网膜脱离的持续时间。该实验可作为玻璃体新生血管形成的动物模型。
